PROCESS FOR PREPARATION OF 2,3-DIHYDROXY BENZONITRILE

摘要

The present invention relates to one pot process for the preparation of 2,3-dihydroxy benzonitrile from 2,3-dialkoxy benzoic acid without prior isolation of the intermediates. Further the invention relates to the preparation of 2,3-dihydroxy benzonitrile by dealkylation of 2,3-dialkoxy benzonitrile using suitable aluminum salt-amine complex.

主权项

1: A one-pot process for the preparation of 2,3-dihydroxy benzonitrile of Formula I, comprising the steps of: a) reacting an acid compound of Formula (II)wherein R1 and R2 are independently represents H or C1-4 alkyl group with a halogenating reagent in presence of a suitable solvent to obtain a corresponding benzoic acid halide;
b) reacting the benzoic acid halide with a source of ammonia to obtain a corresponding amide of Formula III c) treating the amide compound with a dehydrating reagent to obtain a dialkoxy benzonitrile compound of Formula IVand
d) dealkylating the dialkoxy benzonitrile compound of Formula IV with a dealkylating agent in an organic solvent; wherein the steps a) to d) are carried out in a single step without isolating any intermediates.