A CELL CULTURING PLATFORM, A CELL CULTURE SYSTEM, AND A METHOD FOR MODELING MYELINATION IN VITRO

摘要

A cell culturing platform for modeling myelination in vitro comprises first cell chambers (102a, 102b) for containing somas of neuronal cells, a process chamber (103) connected to the first cell chambers with first channels, and a second cell chamber (105) for containing somas of the myelinating cells and connected with second channels to the process chamber. The first channels allow processes of the neuronal cells to enter the process chamber and inhibit the somas of the neuronal cells from moving from the first cell chambers to the process chamber. The second channels allow processes of the myelinating cells to enter the process chamber and inhibit the somas of the myelinating cells from moving from the second cell chamber to the process chamber. Hence, the process chamber, where the myelination takes place, is substantially free from the cell somas and thus detection of the myelination is facilitated.