发明名称 |
A NOVEL PROCESS FOR PREPARATION OF ALOGLIPTIN BENZOATE |
摘要 |
<p>The present invention provides a novel process for preparing Alogliptin free base and its benzoate salt which comprises insitu condensation process to produce protected Alogliptin by reacting 6-chloro-3-methylpyrimidine-2, 4(1H, 3H)-dione with 2-(halo methyl) benzonitirle in presence of a base, aprotic solvent followed by insitu reaction with protected (3R)-piperidin-3-amine at elevated temperature. The protected Alogliptinis deprotected to obtain Alogliptin free base and further converted to Alogliptin benzoate.</p> |
申请公布号 |
WO2015092807(A1) |
申请公布日期 |
2015.06.25 |
申请号 |
WO2014IN00566 |
申请日期 |
2014.09.01 |
申请人 |
HARMAN FINOCHEM LIMITED |
发明人 |
HARMAN FINOCHEM LIMITED;KADAM, VIJAY TRIMBAK;BUDDHALA, RAJASEKHAR RAO;SINGAMPALLLI, SRI HAH;MINHAS, HARPREET SINGH;MINHAS, GURPREET SINGH |
分类号 |
C07C275/24;C07D239/545;C07D403/04 |
主分类号 |
C07C275/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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