THERAPEUTIC AGENTS FOR REDUCING PARATHYROID HORMONE LEVELS

摘要

Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.

主权项

1. A compound comprising a peptide 8 to 15 amino acids in length comprising the amino acid sequence X1-X2-X3-X4-X5-X6-X7,
wherein:
X1 is L-cysteine or D-cysteine,X2 is D-alanine or D-arginineX3 is D-arginine,X4 is D-alanine or D-arginineX5 is D-arginine,X6 is D-alanine, andX7 is D-arginine.