| 发明名称 |
Immunoconjugates with an Intracellularly-Cleavable Linkage |
| 摘要 |
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates. |
| 申请公布号 |
US2015174269(A1) |
申请公布日期 |
2015.06.25 |
| 申请号 |
US201514635530 |
申请日期 |
2015.03.02 |
| 申请人 |
Immunomedics, Inc. |
发明人 |
Govindan Serengulam V.;Moon Sung-Ju;Goldenberg David M. |
| 分类号 |
A61K47/48;C07K16/30;A61K31/4745 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of killing cancer cells, comprising:
a) producing a compound of the structure CL2A-SN-38 by a process comprising the reaction scheme: b) conjugating the CL2A-SN-38 to an antibody moiety (MAb) to produce a structure MAb-CL2A-SN-38, wherein the MAb binds to a tumor-associated antigen (TAA); and c) exposing cancer cells that express the TAA to the MAb-CL2A-SN-38. |
| 地址 |
Morris Plains NJ US |
