A METHOD OF MANUFACTURING A MULTILAYER POLYMER PROTECTIVE COATING FOR IMPLANT MATERIALS WITH A CONTROLLED DRUG RELEASE FUNCTION

摘要

The method of forming a multilayer protective coating for implant materials with a controlled drug release function, wherein a 6 to 20 μηι-thick: parylene layer is applied onto the surface of an implant by chemical vapour deposition, and then treated with oxygen plasma at 0.2 to 1 mbar pressure for 15 to 60 minutes, using a plasma generator of 10 to 60 W power, and then the treated parylene layer is coated with the mixture of lactide and glycolide solutions in the molar ratio of lactide to glycolide of 1 : 1 to 100: 1 together with the drug substance in the amount of 5% to 10% w/w of the polymer material and a polymerisation initiator, and then the polymerisation is performed and the obtained layer is dried.