AQUEOUS RADIATION PROTECTING FORMULATIONS AND METHODS FOR MAKING AND USING THEM

摘要

Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages over other sterilization processes including a high penetrating ability, relatively low chemical reactivity, and instantaneous effects without the need to control temperature, pressure, vacuum, or humidity. Unfortunately, radiation sterilization can compromise the function of certain components of medical devices. For example, radiation sterilization can lead to loss of protein activity and/or lead to bleaching of various dye compounds. Embodiments of the invention provide methods and materials that can be used to protect medical devices from unwanted effects of radiation sterilization.

主权项

1. A composition of matter comprising:
a saccharide sensor comprising:
a saccharide binding polypeptide having a carbohydrate recognition domain; andan aqueous radioprotectant formulation comprising:a saccharide, wherein the saccharide is bound to the carbohydrate recognition domain; andan antioxidant compound, wherein the antioxidant compound is selected from the group consisting of ascorbate, urate, nitrite, vitamin E, α-tocopherol or nicotinate methylester.