发明名称 |
ENHANCED REGIO-SELECTIVITY IN GLYCOL ACYLATION |
摘要 |
A method for acid-catalyzed acylation of an isohexide is described. The method involves a reaction of an isohexide and an excess of carboxylic acid in the presence of a Lewis acid or a Brnsted acid catalyst. One or more Lewis acid or Brnsted acid can faciliate conversion of isohexides to their corresponding mono and diesters with a pronounced greater regio-selectivity of exo-OH over endo-OH of the isohexide in the product. Particular catalytic acid species include zirconium chloride (ZrCl4) and phosphonic acid (H3PO3), which manifest a ratio of exo:endo regioselectivity of about 5.0≠.3:1and about 4.00.3:1, respectively. |
申请公布号 |
WO2015094894(A1) |
申请公布日期 |
2015.06.25 |
申请号 |
WO2014US69698 |
申请日期 |
2014.12.11 |
申请人 |
ARCHER DANIELS MIDLAND COMPANY |
发明人 |
STENSRUD, KENNETH;HAGBERG, ERIK;ROCKAFELLOW, ERIN M. |
分类号 |
C07D493/04;A61K31/424 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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