MONOVALENT ANTI-CD3 ADJUVANTS

摘要

This document provides methods and materials related to using monovalent anti-CD3 antibodies (e.g., monovalent anti-CD3 Fab fragments) as adjuvants to increase the immune response produced against an antigen (e.g., a tumor associated antigen). For example, vaccine compositions containing monovalent anti-CD3γε Fab fragments in combination with tumor associated antigens (e.g., tumor associated antigens having little or no immunogenicity in the absence of monovalent anti-CD3γε Fab fragments) alone or in combination with adjuvants for signals two and/or three required for full activation of T cell immune function, as well as methods and materials for using monovalent anti-CD3γε Fab fragments to increase the immune response produced against an antigen (e.g., a tumor associated antigen) within a mammal (e.g., a human) are provided.

主权项

1. A method for increasing an immune response against an antigen, wherein said method comprises administering a composition comprising a monovalent anti-CD3γε antibody preparation and said antigen or nucleic acid that expresses said antigen to a mammal, wherein said monovalent anti-CD3γε antibody preparation comprises Fab fragments of an anti-CD3γε antibody, and wherein said mammal produces an immune response against said antigen that is increased as compared to an immune response produced against said antigen when said antigen or said nucleic acid is administered to a comparable mammal in the absence of said monovalent anti-CD3γε antibody preparation.