发明名称 |
CELL-PERMEABLE PROBES FOR IDENTIFICATION AND IMAGING OF SIALIDASES |
摘要 |
Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions. |
申请公布号 |
EP2885311(A1) |
申请公布日期 |
2015.06.24 |
申请号 |
EP20130831440 |
申请日期 |
2013.08.16 |
申请人 |
ACADEMIA SINICA |
发明人 |
WONG, CHI-HUEY;FANG, JIM-MIN;CHENG, YIH-SHYUN, E.;TSAI, CHARNG-SHENG |
分类号 |
C07H13/04;C07H13/12;C12N9/24;C12Q1/04;C12Q1/34;C12Q1/40;C12Q1/70 |
主分类号 |
C07H13/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|