| 摘要 |
The present invention provides an aptamer binding to NGF and capable of forming a potential secondary structure represented by the formula (I):
wherein N is one nucleotide selected from the group consisting of A, G, C, U and T,
N11 - N13, N21 - N23, N32 - N38 and N42 - N48 are the same or different and each is a bond or 1 or 2 nucleotides selected from the group consisting of A, G, C, U and T,
N14, N24, N31, N41, N39 and N49 are the same or different and each is one nucleotide selected from the group consisting of A, G, C, U and T,
N14 and N24, N31 and N41, and N39 and N49 each form a Watson-Crick base pair,
N11-N12-N13-N14 and N21-N22-N23-N24 are nucleotide sequences capable of forming a stem structure in combination, and
N31-N32-N33-N34-N35-N36-N37-N38-N39 and N41-N42-N43-N44-N45-N46-N47-N48-N49 are nucleotide sequences capable of forming a stem structure in combination. |
