| 摘要 |
513,060. Cyclopentanophenanthrene compounds. NAAMLOOZE VENNOOTSCHAP ORGANON. March 16, 1938, No. 8178. Convention date, March 17, 1937. [Class 2 (iii)] Cyclopentanodimethylpolyhydro - phenanthrene carboxylic acids or derivatives thereof are obtained by subjecting grignardization products of unsaturated alpha-(cyclopentanodimethylpolyhydrophenanthrene)-propionic acids, the double bonds of which have been saturated with halogen or hydrogen halide and any further oxidizable groups attached to the nucleus have been suitably protected, to the action of a stronger oxidization agent than zone, and isolating the resulting acids. The grignardization product may comprise substituted or unsubstituted tertiary-norcholeniccarbinols. In an example, a grignard's solution prepared from 8 gr. of magnesium and 45 gr. of bromobenzene in absolute ether, is given an addition of 10 gr. of acetoxy-3-#-5, 6-bisnorcholenic acid to give the acylated diol. This is treated with chromic anhydride and glacial acetic acid to give acetoxy-3-#-5, 6- aetrocholenic acid. Specification 443,964 is referred to. |
