Tyrosinase inhibitor produced using dried earthworm powder, and method for producing same

摘要

The present invention provides a highly safe tyrosinase inhibitor having excellent tyrosinase-inhibiting action, and a method for producing the tyrosinase inhibitor. The method for producing a tyrosinase inhibitor comprises the steps of contacting a live earthworm with hydroxycarboxylic acid powder, diluting the resulting mixture with water to adjust the pH to 2 to 5, and then leaving the resulting dilution to stand for 3 to 180 minutes, or contacting a live earthworm with an aqueous solution of hydroxycarboxylic acid having a pH of 2 to 5 and then leaving the resulting mixture to stand for 3 to 180 minutes; followed by washing the live earthworm with water, grinding the washed earthworm, and then freeze-drying the obtained ground product.

主权项

1. A method for producing a tyrosinase inhibitor, comprising the steps of:
contacting a live earthworm with a chloride(s) of at least one metal selected from the group consisting of potassium, sodium, magnesium and calcium; followed by contacting the live earthworm with hydroxycarboxylic acid powder, diluting the resulting mixture with water to adjust the pH to 2 to 5 and then leaving the resulting dilution to stand for 3 to 180 minutes, or contacting the live earthworm with an aqueous solution of hydroxycarboxylic acid having a pH of 2 to 5 and then leaving the resulting mixture to stand for 3 to 180 minutes; followed by washing the live earthworm with water, grinding the washed earthworm, and then freeze-drying the obtained ground product, wherein the step of contacting a live earthworm with a chloride(s) comprises sprinkling a powder of the chloride(s) on the live earthworm and washing the live earthworm with water within 30 minutes after initial contact of the earthworm with the chloride(s).