| 主权项 |
1. A compound of Formula (I), a racemate, an enantiomer or a salt thereof: wherein X is selected from C(═X1), S(═O) and SO2; X1 is selected from O, S and NR4; R1 is optionally substituted and selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, (CH2)tC3-10cycloalkyl, (CH2)tC3-10cycloalkenyl, (CH2)tC6-10aryl, (CH2)t3-10-membered heterocyclyl and (CH2)t5-10-membered heteroaryl, CR5(R6)2, NR4SO2R5, OR6, SR6, NH2, NR5R6 and NRaRb where Ra and Rb join with the N to which they are attached to form an optionally substituted 5-10 membered heterocyclic ring; R2 is optionally substituted and selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, (CH2)tC3-10cycloalkyl, (CH2)tC3-10cycloalkenyl, (CH2)tC6-10aryl, (CH2)t3-10-membered heterocyclyl and (CH2)t5-10-membered heteroaryl; R3 is an optionally substituted C1-6alkyl; R4 is H or an optionally substituted C1-6alkyl; R5 is optionally substituted and selected from C1-6alkyl, C1-6alkoxyl, C2-6alkenyl, C2-6alkynyl, (CH2)tC3-10cycloalkyl, (CH2)tC3-10cycloalkenyl, (CH2)tC6-10aryl, (CH2)t3-10-membered heterocyclyl and (CH2)t5-10-membered heteroaryl; Each R6 is H or is optionally substituted and selected from C1-6alkyl, C1-6alkoxyl, C2-6alkenyl, C2-6alkynyl, (CH2)tC3-10cycloalkyl, (CH2)tC3-10cycloalkenyl, (CH2)tC6-10aryl, (CH2)t3-10-membered heterocyclyl and (CH2)t5-10-membered heteroaryl; t is an integer selected from 0, 1, 2 and 3 wherein each (CH2)t when present may be independently optionally substituted; Z1, Z2 and Z3 are each independently selected from CR7 and N where R7 is selected from H, halo or an optional substituent and further where at least one of Z1, Z2 or Z3 is N; and each cycloalkyl, cycloalkenyl, aryl, heterocyclyl and heteroaryl ring may be a monocyclic or fused bicyclic ring system. |
