发明名称 Peptide compositions and methods for treating patients
摘要 The present invention is directed to peptide compositions and methods of using the peptide compositions to treat prediabetes, diabetes, obesity, high blood pressure and metabolic syndrome.
申请公布号 US9062093(B2) 申请公布日期 2015.06.23
申请号 US201314087247 申请日期 2013.11.22
申请人 THE REGENTS OF THE UNIVERSITY OF MICHIGAN 发明人 Chen Yuqing E.;Xue Changyong;Zhang Jifeng
分类号 A61K38/06;C07K5/04;C07K5/08;C07K5/083 主分类号 A61K38/06
代理机构 Marshall, Gerstein & Borun LLP 代理人 Marshall, Gerstein & Borun LLP
主权项 1. A method for treating a condition comprising administering to a patient an effective amount of a composition, wherein the composition comprises: at least one peptide consisting of the amino acid sequence GGL, GLG, LGL, LLG, LGG, GLL, GGdL, GdLG, GdLL, GLdL, GdLdL, dLLG, LdLG, dLdLG, dLGG, dLGL, LGdL, or dLGdL, or a pharmaceutically acceptable salt of the peptide; at least one peptide consisting of the amino acid sequence GGL, GLG, LGL, LLG, LGG, GLL, GGdL, GdLG, GdLL, GLdL, GdLdL, dLLG, LdLG, dLdLG, dLGG, dLGL, LGdL, or dLGdL, or a pharmaceutically acceptable salt of the peptide, wherein the peptide is acetylated at the N-terminus; at least one peptide consisting of the amino acid sequence GGL, GLG, LGL, LLG, LGG, GLL, GGdL, GdLG, GdLL, GLdL, GdLdL, dLLG, LdLG, dLdLG, dLGG, dLGL, LGdL, or dLGdL, or a pharmaceutically acceptable salt of the peptide, wherein the peptide is amidated at the C-terminus; or at least one peptide consisting of the amino acid sequence GGL, GLG, LGL, LLG, LGG, GLL, GGdL, GdLG, GdLL, GLdL, GdLdL, dLLG, LdLG, dLdLG, dLGG, dLGL, LGdL, or dLGdL, or a pharmaceutically acceptable salt of the peptide, wherein the peptide is acetylated at the N-terminus and amidated at the C-terminus; and wherein the condition is prediabetes, diabetes, obesity, high blood pressure, metabolic syndrome, poor glycemic control, or reduced insulin secretion.
地址 Ann Arbor MI US