摘要 |
This invention relates to a piperazine compound represented by Formula (I),;
wherein
R1 is c1-6 alkyl;R2 is hydroxy, c1-6 alkyl that may have one or more substituents, —(C═O)—N(R2)(R4), or —(C═O)—OR5;R3 and R4 are the same or different, and each represents hydrogen or c1-6 alkyl that may have one or more substituents, orR3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, may form a saturated heterocyclic group; R5 is hydrogen or c1-6 alkyl that may have one or more 15 substituents; andn is 1 or 2;or a salt thereof. |
代理机构 |
Rothwell, Figg, Ernst & Manbeck, P.C. |
代理人 |
Rothwell, Figg, Ernst & Manbeck, P.C. |
主权项 |
1. A method for treating a disease in which prostaglandin D2 or a metabolite thereof participates in a mammal in need of such treatment, the method comprising administering to the mammal, a piperazine compound in an amount effective for treating said disease;
wherein the piperazine compound is represented by Formula (I), whereinR1 is C1-6 alkyl;R2 is hydroxy, C1-6 alkyl that may have one or more substituents, —(C═O)—N(R3)(R4), or —(C═O)—OR5;R3 and R4 are the same or different, and each represents hydrogen or C1-6 alkyl that may have one or more substituents, orR3 and R4, taken together with a nitrogen atom to which R3 and R4 are attached, form a saturated heterocyclic group;R5 is hydrogen or C1-6 alkyl that may have one or more substituents; andn is 1 or 2;or a salt thereof;wherein said substituents on said alkyl groups are selected from the group consisting of halogen, hydroxy, cyano, nitro, alkyl, halogenoalkyl, cycloalkyl, cycloalkyl-alkyl, aralkyl, alkenyl, alkynyl, alkoxy, halogenoalkoxy, cycloalkoxy, cycloalkyl-alkoxy, aralkyloxy, alkylthio, cycloalkyl-alkylthio, amino, mono- or di-alkylamino, cycloalkyl-alkylamino, acyl, acyloxy, oxo, carboxy, alkoxycarbonyl, aralkyloxycarbonyl, carbamoyl, saturated or unsaturated heterocyclic groups, aromatic hydrocarbon, and saturated heterocycloxy groups;wherein the carbamoyl is selected from the group consisting of CONH2, (mono- or di-alkyl) carbamoyl, (mono- or di-aryl) carbamoyl, (N-alkyl-N-aryl) carbamoyl, pyrrolidinocarbamoyl, piperidinocarbamoyl, piperazinocarbaomyl, and morpholinocarbamoyl; andwherein the disease is allergic rhinitis. |