发明名称 |
Methods and compositions for the treatment of symptoms of prion diseases |
摘要 |
A therapeutic composition for the treatment of the symptoms of prion diseases and the method for preparing the therapeutic agents is disclosed. The therapeutic composition is a stable pharmaceutical composition comprising one or more digestive and/or pancreatic enzymes. The therapeutic composition may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic composition may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using fecal chymotrypsin level as a biomarker for the presence of a prion disease, or the likelihood of an individual to develop a prion disease is disclosed. |
申请公布号 |
US9061033(B2) |
申请公布日期 |
2015.06.23 |
申请号 |
US201313737225 |
申请日期 |
2013.01.09 |
申请人 |
CUREMARK LLC |
发明人 |
Fallon Joan M. |
分类号 |
A61K38/54;A61K38/47;C12Q1/37;G01N33/68;A61K38/46;A61K38/48;A61K36/185 |
主分类号 |
A61K38/54 |
代理机构 |
Wilson Sonsini Goodrich & Rosati, P.C. |
代理人 |
Wilson Sonsini Goodrich & Rosati, P.C. |
主权项 |
1. A method for treating one or more symptoms of a prion disease in a patient diagnosed with the prion disease, the method comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition consisting essentially of a mixture of digestive enzymes the mixture comprising at least a protease, an amylase, and a lipase, whereby one or more symptoms of the prion disease is treated; wherein said patient diagnosed with the prion disease has a subnormal level of fecal chymotrypsin. |
地址 |
Rye NY US |