Compositions and methods for treating cancer

摘要

Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tri-carboxylate transporter inhibitor are disclosed. of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.

主权项

1. A method of treating an individual who has cancer that comprises cancer cells that have a high rate of aerobic glycolysis, the method comprising the steps of:
identifying said cancer as a cancer that comprises cancer cells that have a high rate of aerobic glycolysis, wherein said cancer is determined to be a cancer that comprises cancer cells that have a high rate of aerobic glycolysis by PET imaging using 18fluoro-deoxyglucose, and subsequently administering to said individual a therapeutically effective amount of an ATP citrate lyase inhibitor, wherein said therapeutically effective amount of ATP citrate lyase inhibitor is sufficient to inhibit ATP citrate lyase activity in said cancer cells to result in inhibition of conversion of citrate into oxaloacetic and acetyl-CoA in said cancer cells, leading to hyperpolarization of mitochondria and increased reactive oxygen species production sufficient to cause said cell to undergo apoptosis wherein said cancer is selected from the group consisting of glioma, prostate cancer, bladder cancer, renal cancer and lung cancer.