发明名称 |
Compositions and methods for treating IgE-mediated disorders |
摘要 |
The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma. |
申请公布号 |
US9062117(B2) |
申请公布日期 |
2015.06.23 |
申请号 |
US201313784649 |
申请日期 |
2013.03.04 |
申请人 |
Xencor, Inc. |
发明人 |
Desjarlais John;Chu Seung Y.;Horton Holly M.;Bernett Matthew J. |
分类号 |
A61K39/395;C07K16/42;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
Morgan, Lewis & Bockius, LLP |
代理人 |
Silva Robin M.;Nguyen Louis T.;Morgan, Lewis & Bockius, LLP |
主权项 |
1. A method of treating allergic asthma in a patient comprising administering to said patient an anti-IgE antibody comprising: a heavy chain variable region having SEQ ID NO:17 and a light chain variable region having SEQ ID NO:21. |
地址 |
Monrovia CA US |