Zinc oxide-based thin film transistor biosensors with high sensitivity and selectivity

摘要

This application discloses ZnO film transistor-based immunosensors (ZnO-bioTFT), 2T biosensor arrays formed from two integrated ZnO-bioTFTs, 1T1R-based nonvolatile memory (NVM) arrays formed from ZnO-bioTFT (T) integrated with ZnO-based resistive switches (R), as well as integrated bioTFT (IBTFT) sensor systems formed from 2T biosensor arrays and 1T1R NVM arrays. Through biofunctionalization, these biosensors can perform immunosensing with high sensitivity and selectivity, and therefore have a wide range of applications, for example, in detecting target biomolecules or small molecules, and potential application in cancer diagnosis and treatment.

主权项

1. A zinc oxide-based thin film transistor biosensor (ZnO-bioTFT sensor), comprising a ZnO-based thin film transistor (TFT) built on a substrate, wherein said ZnO-TFT has a bottom-gate TFT configuration, said bottom-gate TFT comprising an exposed top channel layer made of a ZnO-based material, said ZnO-based material comprising an undoped or doped MgxZn1-x O (MZO) film, and wherein said exposed top channel layer is biofunctionalized with a linker layer comprising at least one ligand having an affinity for a biomarker.