发明名称 Apparatus, method and system for performing phase-resolved optical frequency domain imaging
摘要 Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.
申请公布号 US9060689(B2) 申请公布日期 2015.06.23
申请号 US200611445990 申请日期 2006.06.01
申请人 The General Hospital Corporation 发明人 Tearney Guillermo J.;Bouma Brett Eugene;De Boer Johannes F.;Vakoc Benjamin J.;Yun Seok-Hyun
分类号 G01N21/55;A61B5/00;G01N21/45;G01N21/47;G01N21/49;G01B9/02 主分类号 G01N21/55
代理机构 Andrews Kurth LLP 代理人 Andrews Kurth LLP
主权项 1. An apparatus comprising: at least one hardware first arrangement including a source which provides a radiation which includes at least one first electro-magnetic radiation directed to a sample and at least one second electro-magnetic radiation directed to a reference, wherein a frequency of the radiation provided by the at least one first arrangement varies over time; and at least one hardware second arrangement which includes a detector that detects a particular interference signal between at least one third radiation associated with the at least one first radiation and at least one fourth radiation associated with the at least one second radiation, wherein that particular interference signal is detected by the detector across a first radiation frequency range, wherein the at least one second arrangement obtains at least one first phase of at least one frequency component of the particular interference signal, and wherein the at least one second arrangement includes a hardware computing arrangement which compares the at least one first phase with at least one second phase of at least one frequency component of a previously-detected interference signal which is detected by the detector across a second radiation frequency range, and wherein the hardware computing arrangement generates at least one image of at least one portion of the sample that substantially excludes information caused by a difference between the first and second radiation frequency ranges based on the comparison and as function of the interference signals.
地址 Boston MA US