Pyrazole azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators

摘要

The present invention relates to pyrazole azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

主权项

1. A compound represented by Formula I, its enantiomers, diastereoisomers, tautomers or a pharmaceutically acceptable salt thereof,wherein:
R is H, optionally substituted C1-6 alkyl, —OC1-3 alkyl, halogen, optionally substituted C6-10 aryl, optionally substituted heterocycle, CN, NO2, C(O)R4, NR5R6 or OH; R1 is H, halogen, optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl, or optionally substituted heterocycle; R2 is H, halogen, optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl, or optionally substituted heterocycle; R3 is H or optionally substituted C1-6 alkyl; R4 is H, OH or optionally substituted C1-6 alkyl; a is 0, 1, 2 or 3; b is 0, 1, 2 or 3; X is S, O, NR5 or CHR6; R5 is H or optionally substituted C1-6 alkyl; and R6 is H or optionally substituted C1-6 alkyl.