Methods of determining renal function using technetium-99m tricarbonyl-nitrilotriacetic acid

摘要

This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracer 99mTc(CO)3(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure encompasses methods of imaging the kidneys and measuring effective renal plasma flow (ERPF) in an animal or human subject using renal scintigraphy, comprising administering to an animal or human subject an amount of a renal tracer, wherein the renal tracer comprises 99mTc-(CO)3(NTA). Another aspect of the disclosure are methods of measuring effective renal plasma flow in an animal or human subject, comprising administering to an animal or human subject an amount of a renal tracer, wherein the renal tracer comprises 99mTc-(CO)3(NTA), isolating a series of plasma samples from the animal or human subject after administering the renal tracer and quantitatively detecting the amount of the renal tracer in the biological samples.

主权项

1. A method of imaging a kidney in an animal or human subject, the method comprising:
(a) administering to an animal or human subject an amount of a renal tracer, wherein the renal tracer comprises technetium-99m tricarbonyl-nitrilotriacetic acid (99mTc(CO)3(NTA)); (b) detecting 99mTc(CO)3(NTA) in the kidney of the animal or human subject with a gamma camera; and (c) obtaining at least one image of the kidney of the animal or human subject, wherein the image is obtained as a data output from a gamma camera.