发明名称 |
METHODS FOR PRODUCING ARIPIPRAZOLE SUSPENSION AND FREEZE-DRIED FORMULATION |
摘要 |
<p>Disclosed are a method for producing an aripiprazole suspension, wherein the aripiprazole has a mean particle size of 1 to 10 ?m, the method comprising the steps of: (a) combining bulk aripiprazole and a vehicle to form a primary suspension; (b) subjecting the primary suspension to first pulverization using e.g., a high shear pulverizing machine, a dispersion machine that applies shear force to a material to be processed, a colloid mill, an ultrasonic dispersion machine, or a high-pressure jet type emulsifying dispersion machine to form a secondary suspension; and (c) subjecting the secondary suspension to second pulverization using e.g., a high-pressure jet type emulsifying dispersion machine to form a sterile final suspension; and a method for producing a freeze-dried formulation from the aripiprazole suspension.</p> |
申请公布号 |
CA2695178(C) |
申请公布日期 |
2015.06.23 |
申请号 |
CA20082695178 |
申请日期 |
2008.07.30 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
HIRAOKA, SHOGO;MATSUDA, TAKAKUNI;HATANAKA, JUNICHI |
分类号 |
A61K9/10;A61K9/19;A61K31/496;A61K47/32;A61K47/38 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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