| 发明名称 | Biological synthesis of difunctional alkanes from carbohydrate feedstocks | ||
| 摘要 | Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid. | ||
| 申请公布号 | US9062314(B2) | 申请公布日期 | 2015.06.23 |
| 申请号 | US201414220677 | 申请日期 | 2014.03.20 |
| 申请人 | Celexion, LLC | 发明人 | Baynes Brian M.;Geremia John Michael |
| 分类号 | C12P17/10;C12N9/00;C12N1/20;C12N15/00;C07H21/04;C12N15/77;C12P7/18;C12P7/42;C12P7/44;C12P7/50;C12P13/00;C12P13/02;C12N15/70 | 主分类号 | C12P17/10 |
| 代理机构 | Greenberg Traurig LLP | 代理人 | Greenberg Traurig LLP ;Salem Natalie |
| 主权项 | 1. A genetically modified host cell that produces a metabolic intermediate selected from adipic acid semialdehyde, and alpha aminopimelic acid, wherein the genetically modified host cell comprises one or more exogenous nucleotide sequences encoding at least one polypeptide selected from homocitrate synthase, homoaconitase, homoisocitrate dehydrogenase, homo2citrate synthase, homo2 aconitase, homo2isocitrate dehydrogenase, and at least one polypeptide selected from the group consisting of 2-aminotransferase, and 2-ketoacid decarboxylase. | ||
| 地址 | Cambridge MA US | ||