Pharmaceutical composition for treating wounds or revitalizing skin comprising <i>Euphorbia kansui </i>extracts, fractions thereof or diterpene compounds separated from the fractions as active ingredient

摘要

The present invention relates to a pharmaceutical composition for treating wounds or revitalizing skin comprising the Euphorbia kansui extract, the fractions thereof, or the diterpene compound isolated therefrom as an active ingredient. The Euphorbia kansui extract may act on epithelial cells to induce PKD1 activity required for improving the reproduction capability of differentiated epithelial cells, and thus may induce the phosphorylation of lower ERK1 and the generation of Cycline D, thus exhibiting an excellent ability to activate the reproduction of damaged skin. Therefore, the Euphorbia kansui extract may be used effectively as an active ingredient in a pharmaceutical composition for treating wounds or reproducing skin, a health food for recovering skin damage or reproducing skin, or a functional cosmetic for inducing skin cell activity.

主权项

1. A method for treating a mammal suffering from a wound on the skin of the mammal comprising topically administering a therapeutically effective amount of an extract of the stems or leaves of Euphorbia kansui to the skin of the mammal to effectively treat the wounds on the skin of the mammal, wherein the extract is obtained by using an organic solvent selected from the group consisting of ethyl acetate, chloroform, butyl acetate, hexane, and diethyl ether.