Methods of treating a <i>Flaviviridae </i>family viral infection and compositions for treating a <i>Flaviviridae </i>family viral infection

摘要

Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.

主权项

1. A method of treating a host infected with Hepatitis C virus, the method comprising administering to the host a therapeutically effective amount of an inhibiting agent, or a pharmaceutical salt thereof, to reduce the viral load in the host, wherein the inhibiting agent is a compound having the formula: wherein R1 is selected from the group consisting of R2 is selected from the group consisting of: —H, —CH3, —CF3, —CH2CH3, CH2OH,and
R4 to R7 are each independently selected from the group consisting of: —H, —CH3, and a halogen.