Combination therapy with interferon and andrographolides for Multiple Sclerosis

摘要

The effectiveness of interferon for treating multiple sclerosis and other demyelinating diseases is synergistically potentiated by concomitant administration of a compound of Formula (I): wherein R1 is H, alkyl or OH, R2 is hydroxyalkyl or alkyl-O-L1, R3 is H or OH, X is C(═CH2), CH(OH), or spirooxirane-2, Z is CH2CH(OH) or C(=0), and R4 is an optionally substituted L2-alkyl or L2-alkenyl, wherein L2 is an optionally substituted 3-furanyl or 3-fur-3-enyl moiety.;

主权项

1. A method for treating multiple sclerosis in a human patient by providing beta interferon to said a human patient, the improvement comprising administering to said human patient a compound of Formula I: wherein
R1 is selected from the group consisting of hydrogen, alkyl or hydroxyl,R2 is selected from the group consisting of hydroxyalkyl or alkyl-O-L1, wherein L1 is a carbohydrate moiety,R3 is selected from the group consisting of hydrogen or hydroxyl,X is selected from the group consisting of C(═CH2), CH(OH), or a spirooxirane-2 moiety,Z is selected from the group consisting of CH2, CH(OH) or C(═O), andR4 is selected from the group consisting of an optionally substituted L2-alkyl or L2-alkenyl, wherein L2 is an optionally substituted 3-furanyl or 3-fur-3-enyl moiety, or a pharmaceutically acceptable salt, ester, ether or prodrug thereof.