| 发明名称 | Marker associated with non-alcoholic steatohepatitis | ||
| 摘要 | Disclosed is a novel NASH marker for use in a method for detecting NASH or evaluating the severity of NASH, which utilizes at least one factor selected from the group consisting of an IL-1 receptor antagonist, sCD40, HMGB1, sPLA2 group IIA and an sPLA2 activity as the marker. Also disclosed is a method for detecting NASH or evaluating the severity of NASH in a subject, which utilizes the marker. | ||
| 申请公布号 | US9060981(B2) | 申请公布日期 | 2015.06.23 |
| 申请号 | US201013500753 | 申请日期 | 2010.10.15 |
| 申请人 | MOCHIDA PHARMACEUTICAL CO., LTD. | 发明人 | Sato Ayumi;Harada Tsuyoshi;Yano Takashi;Wakabayashi Yoko |
| 分类号 | G01N33/53;A61K31/202;G01N33/576;G01N33/68 | 主分类号 | G01N33/53 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. A method for detecting a non-alcoholic steatohepatitis (NASH) or evaluating seriousness thereof comprising: (A) measuring an amount and/or activity level of IL-1 receptor antagonist in a biological specimen from a subject as a marker by immunoassay; and (B) determining if said subject has NASH or evaluating seriousness thereof by comparing the measured value of step (A) with a cut off value, wherein the cut off value is the borderline between positive and negative of a disease, and the cut off value for said IL-1 receptor antagonist is 652 pg/mL. | ||
| 地址 | Tokyo JP | ||