| 发明名称 | Treatment of degenerative joint disease | ||
| 摘要 | The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP. | ||
| 申请公布号 | US9060968(B2) | 申请公布日期 | 2015.06.23 |
| 申请号 | US201213681618 | 申请日期 | 2012.11.20 |
| 申请人 | Ampio Pharmaceuticals, Inc. | 发明人 | Bar-Or David;Winkler James V. |
| 分类号 | A61K38/00;A61P19/02;A61K38/12;A61K45/06;A61K31/20;A61K31/405 | 主分类号 | A61K38/00 |
| 代理机构 | Sheridan Ross P.C. | 代理人 | Sheridan Ross P.C. |
| 主权项 | 1. A method of reducing the pain associated with osteoarthritis of the knee comprising administering an intra-articular injection to a knee of an animal in need thereof, an effective amount of a pharmaceutical composition comprising an aspartic acid-alanine diketopiperazine (DA-DKP), in a concentration from about 50 μM to about 350 μM, wherein the composition further comprises N-acetyl-tryptophan (NAT) and caprylate and wherein the administration provides reduction in knee pain. | ||
| 地址 | Englewood CO US | ||