METHOD FOR PRODUCTION OF LENALIDOMIDE

摘要

Improvements in the preparation process of 3-(4-amino-1-oxo-1,3-dihydro-2H- isoindol-2-yl)piperidine-2,6-dione (Ienalidomide), wherein the intermediate 2-methyl- 3-nitrobenzoic acid methyl ester is brominatcd with N-bromosuccinimide in methyl acetate and the end product is obtained from 3-(4-nitro-l-oxo-l,3-dihydro- 2H-isoindol-2-yl)piperidine-2,6-dione by reducing with iron and ammonium chloride reducing system.