发明名称 AN ANTIBODY INDUCING ANTIGEN-SPECIFIC CELL OLERANCE AND USE THEREOF
摘要 The present invention relates to an antibody binding to the domain 2 of human intercellular adhesion molecules-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and induce antigen-specific T cell tolerance, thereby be effective in the prevention and/or treatment of T cell-mediated immune disorders such as transplantation rejection, graft-versus-host disease, and autoimmune disease. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease.
申请公布号 HK1198699(A1) 申请公布日期 2015.06.19
申请号 HK20140112219 申请日期 2014.12.04
申请人 发明人 PARK, SEONG HOE;JUNG, KYEONG CHEON
分类号 C07K;A61K;A61P;C12N 主分类号 C07K
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