| 摘要 |
<p>The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a aukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of comprehensive integrated antibody optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.</p> |
