CRYSTALLINE FORM OF TYROSINE KINASE NHIBITOR DIMALEATE AND PREPARATION METHODS THEREOF

摘要

Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl -methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrr olidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmaceutical composition containing the same. Said crystalline Form I of SHR1258 dimaleate has good crystal stability and chemical stability, and can be used in preparation of medicaments for treating diseases relevant to EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase.