发明名称 |
HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3), AND USES THEREOF |
摘要 |
The present disclosure provides isolated human monoclonal antibodies and antigen-binding portions thereof that bind to human LAG-3, in particular antibodies and antigen-binding antibody portions that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T cell responses. Nucleic acid molecules encoding the antibodies and antigen-binding antibody portions of the invention as well as compositions and immunoconjugates of the antibodies and antigen-binding antibody portions of the invention are also provided. This disclosure also provides for the use of the antibodies and antigen-binding antibody portions of the invention in therapy. |
申请公布号 |
PT2320940(E) |
申请公布日期 |
2015.06.19 |
申请号 |
PT20090807162T |
申请日期 |
2009.08.11 |
申请人 |
E. R. SQUIBB & SONS, L.L.C. |
发明人 |
KENT B. THUDIUM;ALAN J. KORMAN;HEIDI LEBLANC;MARK YAMANAKA;MARK SELBY |
分类号 |
C12N5/16 |
主分类号 |
C12N5/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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