发明名称 |
IL-31 MONOCLONAL ANTIBODIES AND METHODS OF USE IL-31 |
摘要 |
<p>There is provided an isolated monoclonal antibody or antigen-binding fragment thereof that competes with the monoclonal antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815 for binding to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:2; wherein the monoclonal antibody has a human IgG4 heavy chain immunoglobulin constant domain or wherein the antigen-binding fragment further comprises a human IgG4 heavy chain immunoglobulin constant domain; and wherein the monoclonal antibody or antigen-binding fragment inhibits signal transduction induced by the polypeptide through its heterodimeric receptor.</p> |
申请公布号 |
HK1199047(A1) |
申请公布日期 |
2015.06.19 |
申请号 |
HK20140112678 |
申请日期 |
2014.12.17 |
申请人 |
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发明人 |
SIADAK, ANTHONY W.;BILSBOROUGH, JANINE;RENE, SHIRLEY |
分类号 |
C07K;A61K;A61P;C12N |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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