NANOPARTICLE PEPTIDE COMPOSITIONS

摘要

The present invention provides nanoparticles and compositions comprising such nanoparticles as well as methods for intracellular delivery of peptides and methods of producing nanoparticles and related products. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker. The second linker comprises a peptide portion and a non peptide portion wherein said peptide portion of said second linker comprises the sequence XXZ wherein: X is an amino acid selected from A and G; X is an amino acid selected from A and G; and Z is an amino acid selected from Y and F.