MARKER PEPTIDES FOR DETERMINING THE OCCURRENCE OF AN INFLAMMATORY STATE IN A SUBJECT

摘要

An enzyme proteolysis-resistant peptide that binds to antibodies directed against the amino acid region 1-116 of the endocan's polypeptide sequence, which peptide possesses an apparent molecular weight of 14 kDa.

主权项

1. A method for determining the occurrence of an inflammatory state in a subject, comprising the steps of:
a) providing a sample previously collected from the said subject, b) measuring the amount value of: (i) at least one enzyme proteolysis-resistant peptide that binds to antibodies directed against the amino acid region 1-116 of the endocan polypeptide sequence of SEQ ID NO: 1, which peptide possesses an apparent molecular weight of 14 kDa, and (ii) of human endocan of SEQ ID NO: 1, in the said sample, c) determining the inflammatory state of the said subject from the ratio of the amount values of (i) the at least one enzyme proteolysis-resistant peptide measured at step b), to (ii) the human endocan measured at step b).