DNA VACCINE FOR USE IN PANCREATIC CANCER PATIENTS

摘要

The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding a VEGF receptor protein. In particular, the present invention relate to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy.

主权项

1. An attenuated mutant strain of Salmonella typhi comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding a VEGF receptor protein, particularly a VEGF receptor protein selected from the group consisting of human VEGFR-2 and a homolog thereof that shares at least about 80% homology therewith, particularly wherein human VEGFR-2 has the amino acid sequence as found in SEQ ID NO 1, for use as a vaccine.