主权项 |
1. A peptidic compound having the formula (I):
R1—Z—R2 (I) wherein Z is a peptide moiety having the formula (II)
Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Ile-Gln-X14-Glu-X16-Glu-Ala-Val-X20-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-X40 (II) X14 represents an amino acid residue selected from Met, Leu, Nle, Met(O) or Met(O2), X16 represents an amino acid residue selected from Lys or Glu, X20 represents an amino acid residue selected from Arg, Aib, (S)Me-Lys, (R)Me-Lys, or (S)Me-Orn, X40 is absent or represents Lys, R1 represents NH2, and R2 represents OH or NH2, or a salt or solvate thereof. |