发明名称 |
METHOD OF EVALUATING PHARMACEUTICAL PREPARATION CONTAINING LULICONAZOLE AND INDEX SUBSTANCE |
摘要 |
Disclosed is a method of evaluating stability of a pharmaceutical preparation containing luliconazole. The method includes measuring an amount of production of an SE form of luliconazole represented by following formula (2), an amount of production of a Z form of luliconazole represented by following formula (3) and an amount of production of an amide form of luliconazole represented by following formula (1) after storage under a severe condition or an accelerated condition, and judging that the stability of the pharmaceutical preparation is high if each of the amount of production of the SE form, the amount of production of the Z form and the amount of production of the amide form is not more than 5% by weight with respect to a compounded amount of luliconazole.; |
申请公布号 |
US2015168357(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
US201514592695 |
申请日期 |
2015.01.08 |
申请人 |
POLA PHARMA INC. ;NIHON NOHYAKU CO., LTD. |
发明人 |
Masuda Takaaki;Yamaguchi Hiroshi |
分类号 |
G01N30/02 |
主分类号 |
G01N30/02 |
代理机构 |
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代理人 |
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主权项 |
1. A method of evaluating stability of a pharmaceutical preparation comprising luliconazole, comprising: measuring an amount of production of an SE form of luliconazole represented by following formula (2), an amount of production of a Z form of luliconazole represented by following formula (3) and an amount of production of an amide form of luliconazole represented by following formula (1) after storage under a severe condition or an accelerated condition, and judging that the stability of the pharmaceutical preparation is high if each of the amount of production of the SE form, the amount of production of the Z form and the amount of production of the amide form is not more than 5% by weight with respect to a compounded amount of luliconazole. |
地址 |
Tokyo JP |