发明名称 PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS
摘要 The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.
申请公布号 WO2015089361(A1) 申请公布日期 2015.06.18
申请号 WO2014US69916 申请日期 2014.12.12
申请人 VERTEX PHARMACEUTICALS INCORPORATED 发明人 ANDERSON, COREY;HADIDA-RUAH, SARA, SABINA;GOLEC, JULIAN MARIAN, CHARLES;ZHANG, BEILI;LITTLER, BENJAMIN, JOSEPH;KESHAVARZ-SHOKRI, ALI;ALCACIO, TIM, EDWARD;BELMONT, DANIEL, T.
分类号 C07F9/576;A61K31/675;A61P19/02 主分类号 C07F9/576
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