发明名称 |
METHOD FOR PREPARING SILODOSIN AND INTERMEDIATE THEREOF |
摘要 |
Provided is a method for preparing silodosin. Also provided is a method for preparing an organic acid salt of a new intermediate 3-(7-cyano-5-((R)-2-((R)-1-phenylethylamino)propyl)-1-hydrogen-indolyl) propyl alcohol (ester or ether), and a new intermediate 3-(7-cyano-5-((R)-2-(((R)-1-phenethyl)(2-(2-(trifluoroethoxy)phenoxy) ethyl)amino)propyl)1-hydrogen-indolyl)propyl alcohol (ester or ether) and a salt thereof. The method has the following advantages: raw materials are cheap and easy to obtain, the operation is simple, the intermediate and product are easy to purify, the yield is high, and the method is applicable to industrial production. |
申请公布号 |
WO2015085827(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
WO2014CN88953 |
申请日期 |
2014.10.20 |
申请人 |
SHANGHAI SYNCORES TECHNOLOGIES, INC.;ZHEJIANG HUAHAI PHARMACEUTICALS CO., LTD. |
发明人 |
XIONG, ZHIGANG;CAO, JIAN;CHEN, LIUSHAN;HUANG, LUNING;ZHANG, XINI |
分类号 |
C07D209/08 |
主分类号 |
C07D209/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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