| 摘要 |
<p>Method of making different composition of fluoride added phosphate based glasses and their use thereof are disclosed. The physical properties of the fluoride added phosphate based glasses were assessed using density measurements, ultrasonic velocity measurements, XRD patterns, FTIR spectra, pH variations during 21 days of in vitro studies in SBF solution, SEM images, EDS spectra and XPS spectrograph. A rich layer of HAp is formed on the surface of fluorophosphate glasses during in vitro studies. The ex vivo cell culture studies confirmed that the prepared glasses are non-toxic. The bioconversion was confirmed using in vivo animal studies by implanting the glass into femoral condyle of matured rabbits for 10 weeks followed by SEM images, EDS spectra, CLSM images. Of all the combinations, glass sample FP3 was found to be more suitable for future clinical applications.</p> |
