发明名称 |
FUSED TRICYCLIC BENZIMIDAZOLES DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
摘要 |
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H- imidazo [1,2-a]benzimidazo le, dihydro-1H-pyrrolo [1,2-a]benzimidazo le, dihydro-1H- pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. |
申请公布号 |
CA2932008(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
CA20142932008 |
申请日期 |
2014.12.08 |
申请人 |
UCB BIOPHARMA SPRL |
发明人 |
ALEXANDER, RIKKI PETER;CALMIANO, MARK DANIEL;DEFAYS, SABINE;DURIEU, VERONIQUE;DELIGNY, MICHAEL;HEER, JAG PAUL;JACKSON, VICTORIA ELIZABETH;KEYAERTS, JEAN;KROEPLIEN, BORIS;MAC COSS, MALCOLM;SABNIS, YOGESH ANIL;SELBY, MATTHEW DUNCAN;SWINNEN, DOMINIQUE LOUIS LEON;VAN HOUTVIN, NATHALIE;ZHU, ZHAONING;HEINELT, UWE;WEHNER, VOLKMAR |
分类号 |
C07D471/04;A61K31/437;A61P29/00;C07D487/04;C07D498/04;C07D519/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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地址 |
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