摘要 |
A series of substituted fused tricyclic imidazole derivatives, in particular dihydro- 1H-pyrano[4',3':4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4- c']dipyridine, dihydro-1H-pyrano[3',4':4,5]imidazo[1,2-a]pyridine and tetrahydro-6H- cyclohepta[4,5]imidazo[1,2-a]pyridine, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. |
申请人 |
UCB BIOPHARMA SPRL |
发明人 |
ALEXANDER, RIKKI PETER;BROWN, JULIEN ALISTAIR;DELIGNY, MICHAEL;HEER, JAG PAUL;JACKSON, VICTORIA ELIZABETH;JADOT, SOPHIE;KROEPLIEN, BORIS;MAC COSS, MALCOLM;SABNIS, YOGESH ANIL;SWINNEN, DOMINIQUE LOUIS LEON;VAN HOUTVIN, NATHALIE;ZHU, ZHAONING |