METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS

摘要

The invention provides methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention provides a microarray for obtaining gene expression data from a lymphoma sample. The invention also provides a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma, which is useful in developing an appropriate therapeutic approach.

主权项

1. A method for predicting survival in a follicular lymphoma (FL) subject comprising the steps of:
a) isolating gene expression product from a biopsy sample from a subject; b) obtaining gene expression data from the isolated gene expression product, wherein the gene expression data comprises data for genes in an immune response-1 gene expression signature and genes in an immune response-2 gene expression signature; c) obtaining an average gene expression level for the genes in the immune response-1 gene expression signature to thereby obtain an immune response-1 gene expression signature value; d) obtaining an average gene expression level for the genes in the immune response-2 gene expression signature to thereby obtain an immune response-2 gene expression signature value; and f) calculating a survival predictor score using an equation: [2.71*(immune response-2 gene expression signature value)]−[2.36*(immune response-1 gene expression signature value)]; wherein a higher survival predictor score is associated with worse survival.