Methods for Evaluating Alzheimer's Disease and Disease Severity

摘要

A method for diagnosing and/or evaluating dementia severity in a subject suspected of having or having dementia is provided the method comprising:
a) obtaining a test cell sample from the subject,b) assaying the test cell sample to determine a telomere organization signature of the test sample, the telomere organization signature comprising one or more parameters selected from:i) telomere aggregates;ii) telomere number;iii) telomere length and telomere number;iv) telomere aggregates, telomere length and telomere numbers;c) comparing the test cell sample telomere organization signature to a control or one or more predetermined reference signatures; andd) diagnosing whether the subject has dementia and/or the dementia severity according to the test sample telomere organization signature.

主权项

1. A method for evaluating and/or diagnosing a subject having or suspected of having Alzheimer's disease comprising:
a) obtaining a test cell sample from the subject, b) assaying the test cell sample using 3D analysis to determine one or more telomere organization signature of the test sample, the telomere organization signature comprising one or more parameter values selected from: i) telomere aggregates; ii) telomere number; iii) telomere length and telomere number; and iv) telomere aggregates, telomere length and telomere numbers; c) comparing the test cell sample telomere organization signature to one or more predetermined reference signatures, each reference signature comprising a control and/or one or more reference parameter values; and d) evaluating and/or diagnosing whether the subject has AD and/or is likely to develop AD according to the test sample telomere organization signature.