发明名称 |
METHODS FOR TREATING HYPERCHOLESTEROLEMIA |
摘要 |
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides. |
申请公布号 |
US2015167005(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
US201414539831 |
申请日期 |
2014.11.12 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
Freier Susan M.;Crooke Rosanne M.;Graham Mark J.;Lemonidis Kristina M.;Bhanot Sanjay;Tribble Diane;Watt Andrew T. |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
CARLSBAD CA US |