| 发明名称 |
METHODS AND COMPOSITIONS |
| 摘要 |
The invention relates to a complex comprising a phage particle, said phage particle comprising
(i) a polypeptide;(ii) a nucleic acid encoding the polypeptide of (i);(iii) a connector compound attached to said polypeptidewherein said connector compound is attached to the polypeptide by at least three discrete covalent bonds. The invention also relates to libraries, and to methods for making complexes and to methods of screening using same. |
| 申请公布号 |
US2015166988(A1) |
申请公布日期 |
2015.06.18 |
| 申请号 |
US201414339327 |
申请日期 |
2014.07.23 |
| 申请人 |
BICYCLE THERAPEUTICS LIMITED |
发明人 |
Winter Gregory Paul;Heinis Christian |
| 分类号 |
C12N15/10;C07K14/005;C07K1/107 |
主分类号 |
C12N15/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A genetically encoded polypeptide library of complexes comprising a nucleic acid encoding a polypeptide, wherein:
(i) the polypeptide encoded by the nucleic acid is linked to the nucleic acid; (ii) a connector compound attached to said polypeptide; (iii) the connector compound is attached to the polypeptide by at least three discrete covalent bonds; and (iv) the library is a mRNA display, DNA display, yeast display, ribosome display or bacterial display library. |
| 地址 |
CAMBRIDGE GB |
